Super Tadalis SX contains Tadalafil, a PDE5 inhibitor used for erectile dysfunction (ED). It should never be mixed with nitrates (like nitroglycerin, isosorbide mononitrate) because of a dangerous interaction that can severely lower blood pressure. Here’s why, step by step: How Tadalafil works: Tadalafil relaxes blood vessels in the ***** to increase blood flow. This relaxation also slightly lowers blood pressure systemically. How nitrates work: Nitrates are vasodilators—they widen blood vessels to relieve chest pain (angina). They already lower blood pressure as part of their effect. The dangerous interaction: Taking both together causes excessive vasodilation, which can lead to a sudden, severe drop in blood pressure. Symptoms may include dizziness, fainting, heart palpitations, or even heart attack or stroke in severe cases. Medical guideline: Patients using nitrates should never use PDE5 inhibitors, including Super Tadalis SX, under any circumstance. If someone on nitrates needs ED treatment, a doctor may suggest alternative therapies.