Tazzle 10 mg (tadalafil) can cause flushing because tadalafil causes vasodilation—it relaxes blood-vessel smooth muscle by increasing the effects of nitric-oxide/cGMP signaling. This can temporarily increase blood flow to the skin, producing warmth, redness, or a “hot face” sensation. D DailyMed +1 At 10 mg, flushing was reported in about 3% of patients in clinical trials, compared with about 1% with placebo. D DailyMed Usually, mild flushing is not dangerous and settles as the drug wears off. It can be more noticeable with alcohol or other medicines that lower blood pressure. However, seek medical attention if flushing is accompanied by severe dizziness/fainting, chest pain, difficulty breathing, or a very rapid/irregular heartbeat. If you tell me how long after Tazzle 10 mg you get flushing and how long it lasts, I can explain whether that pattern is typical.