If Sildisoft is the sildenafil product used for erectile dysfunction, the following people should avoid it or use it only after medical advice: Anyone taking nitrate medicines such as nitroglycerin or isosorbide, including recreational “poppers.” The combination can cause a dangerous fall in blood pressure. D DailyMed +1 People taking riociguat or another guanylate-cyclase stimulator. D DailyMed Anyone with a known allergy to sildenafil or its ingredients. D DailyMed People for whom ***** activity itself is medically inadvisable, such as some patients with serious or unstable cardiovascular disease. D DailyMed People with very low blood pressure, or certain severe heart, liver, or kidney conditions, should be assessed by a doctor before use. P Pi-Pil Repository Also, sildenafil can lower BP further when combined with alpha-blockers or other blood-pressure medicines, so medical guidance may be needed. D DailyMed If you tell me your BP reading and the names/doses of your current BP medicines, I can tell you whether sildenafil is likely to be a concern with them.