Cenforce 130 mg (which contains Sildenafil 130 mg) with other drugs: 1. Nitrate Medications Examples: Nitroglycerin, isosorbide mononitrate, isosorbide dinitrate. Risk: Combining Sildenafil with nitrates can cause a dangerous drop in blood pressure, leading to dizziness, fainting, heart attack, or stroke. 2. Certain Blood Pressure Medications Alpha-blockers (like doxazosin, tamsulosin) or some antihypertensives. Risk: Sildenafil can enhance the blood pressure-lowering effects, increasing the chance of dizziness or fainting. 3. Other ED Medications Other PDE5 inhibitors (like Tadalafil, Vardenafil). Risk: Combining them can increase side effects such as headaches, flushing, or heart issues without improving effectiveness. 4. HIV Protease Inhibitors or Certain Antibiotics Examples: Ritonavir, erythromycin, ketoconazole. Risk: These drugs can increase Sildenafil levels in the blood, raising the risk of side effects. 5. Heart or Liver Disease Patients Anyone with severe heart problems (unstable angina, recent heart attack) or severe liver/kidney impairment should avoid combining Cenforce with certain medications, as this may strain the heart or cause toxicity. Bottom line: Cenforce 130 mg should not be combined with nitrates, some blood pressure medications, other ED drugs, or certain liver-metabolized medications. Always consult a doctor or pharmacist before taking it with any prescription or over-the-counter drugs.