Vidalista 80 (tadalafil 80 mg) drug interactions should be checked by a healthcare professional, especially because tadalafil can interact with medicines that affect blood pressure and heart function. The main people who can review this safely are: A doctor (especially your prescriber or urologist) — can review your medical conditions and all medicines you take. A pharmacist — can check your full medication list for drug–drug interactions. A cardiologist — if you have heart disease, chest pain, blood pressure problems, or heart medications. Important interactions to check include: Nitrates (such as nitroglycerin or isosorbide medicines): should not be combined with tadalafil because it can cause a dangerous drop in blood pressure. Alpha-blockers (some prostate or blood pressure medicines): may increase the risk of low blood pressure and dizziness. Certain antifungals, antibiotics, HIV medicines, seizure medicines, and other ED medicines can also affect tadalafil levels or increase side effects. Because Vidalista 80 is a high tadalafil dose, an interaction check is especially important before use.