Tadarise 60 mg has fewer interactions” you mean different versions/brands of Tadarise 60 mg: the interaction profile depends mainly on the active ingredients and dose, not the brand name. Tadarise 60 mg is marketed as tadalafil 60 mg. S Sunrise Remedies +1 More importantly, 60 mg tadalafil is above the usual approved on-demand ED dose of 20 mg, so I would not consider it a lower-interaction option simply because it is Tadarise. The major interactions with tadalafil include: Nitrates (nitroglycerin, isosorbide): contraindicated because of potentially dangerous blood-pressure lowering. The interaction can remain clinically important for at least 48 hours after tadalafil. D DailyMed +1 Alpha-blockers such as tamsulosin/doxazosin: can further lower blood pressure. D DailyMed Some antihypertensives: additive blood-pressure lowering can occur. D DailyMed Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, erythromycin/clarithromycin and ritonavir can substantially increase tadalafil exposure. D DailyMed +1 Other ED medicines, such as sildenafil (Penegra/Fildena), should not be combined with tadalafil because of additive effects and increased adverse effects. If you give me the exact medicines/supplements you currently take (including blood-pressure, heart, prostate, antidepressant, or HIV medicines), I can check which interactions are relevant and whether tadalafil is appropriate.