Vidalista 60 contains 60 mg of tadalafil, which affects vascular function primarily by causing vasodilation (widening of blood vessels). Here's where and how it acts: Penile blood vessels (main therapeutic target) Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE5). This increases levels of cyclic GMP (cGMP) in smooth muscle cells. Higher cGMP causes relaxation of smooth muscle in the arteries and erectile tissue of the *****. As a result, blood flow into the ***** increases during ***** stimulation, facilitating erection. Systemic blood vessels PDE5 is present elsewhere in the body, so tadalafil can produce mild vasodilation in other vascular beds. This can lead to: Slight decreases in blood pressure Flushing Headache Nasal congestion Dizziness in some people Pulmonary vasculature Tadalafil also relaxes blood vessels in the lungs. In different formulations and dosing regimens, tadalafil is used to treat Pulmonary Arterial Hypertension by lowering pulmonary artery pressure. Prostate and bladder neck smooth muscle Tadalafil can relax smooth muscle in the lower urinary tract, which is why it is also approved for symptoms of Benign Prostatic Hyperplasia. Impact of the 60 mg dose A 60 mg dose is substantially higher than the commonly prescribed 10–20 mg as-needed dose for erectile dysfunction. Higher doses may produce: More pronounced vasodilation Greater risk of headache, flushing, low blood pressure, and dizziness Increased likelihood of side effects without necessarily providing proportionally greater benefit Particular concern If you are asking about vascular function because of: Heart disease High or low blood pressure Use of nitrates (nitroglycerin, isosorbide) Alpha-blockers Exercise performance or circulation the answer becomes more specific, since tadalafil's vascular effects can be clinically important in those situations. Let me know which aspect you're interested in.