You can find reliable tadalafil precautions in these sources: DailyMed tadalafil prescribing information — includes contraindications, cardiovascular precautions, interactions, vision/hearing warnings, and priapism. MedlinePlus tadalafil precautions — provides patient-friendly information about medicines that should not be combined with tadalafil, including nitrates and riociguat. For Tadasoft 40 mg specifically, verify the package ingredients because brand formulations can vary. If it contains tadalafil 40 mg, important precautions include avoiding nitrates, riociguat, and other PDE5 inhibitors. Tadalafil can also lower blood pressure, particularly with alpha-blockers, antihypertensives, or substantial alcohol. D DailyMed +1 One important point: 40 mg tadalafil is not the usual ED dose; 40 mg once daily is an established tadalafil dose for pulmonary arterial hypertension. D DailyMed If you're considering Tadasoft 40 mg for ED, I can explain the appropriate tadalafil doses and the main precautions in about 200 words.