Malegra DXT Plus is a medication typically used to treat erectile dysfunction and contains two active ingredients: Sildenafil (the same active ingredient in Viagra) and Dapoxetine (a selective serotonin reuptake inhibitor or SSRI used for premature *****). The effects of Malegra DXT Plus can vary based on the individual, but here’s a general idea: Sildenafil (for erectile dysfunction): It usually takes around 30 to 60 minutes to start working, and its effects can last anywhere from 4 to 6 hours. However, this can depend on factors like your metabolism, whether you've eaten, and your general health. Dapoxetine (for premature *****): This works a bit differently. The peak effect of Dapoxetine usually occurs within about 1 to 2 hours after ingestion, and its effects may last around 4 to 6 hours as well. So, overall, the medication will likely "wear off" in about 4 to 6 hours, though it may still have some residual effects after that period, especially if you've taken it on an empty stomach or have a higher metabolism.