Tadarise Black 80 mg (which contains tadalafil) should generally not be taken together with alpha-blockers used for prostate enlargement or high blood pressure, unless a doctor specifically adjusts the doses and timing. hen it should NOT be taken with alpha-blockers Avoid combining them in these situations: If you are just starting an alpha-blocker (first few days or dose changes) If you are on a high dose of an alpha-blocker (risk of strong blood pressure drop) If you already experience dizziness, fainting, or low blood pressure If tadalafil (Tadarise Black 80 mg) is taken at full/high dose without medical supervision If the combination is not medically planned with time separation   Why this combination is risky Both tadalafil and alpha-blockers (like tamsulosin, alfuzosin, doxazosin) relax blood vessels. When taken together, they can cause: Sudden drop in blood pressure Dizziness or fainting Blurred vision or weakness In severe cases, falls or injury due to loss of balance  When it may be allowed (only under doctor control) Doctors may sometimes allow both, but only if: The patient is stable on alpha-blocker therapy Tadalafil is started at a lower dose first Doses are staggered in time (not taken together at the same moment) Blood pressure is monitored Bottom line Tadarise Black 80 mg should not be combined with alpha-blockers during initiation, dose escalation, or without medical supervision, because the risk of dangerous blood pressure drop is significantly higher.