Super P-Force Oral Jelly (sildenafil + dapoxetine) should never be mixed with nitrates at any time — the combination is strictly contraindicated. When exactly should it NOT be mixed with nitrates? You must avoid nitrates completely if: You are taking nitrate medicines for chest pain (angina) such as: nitroglycerin (GTN) isosorbide mononitrate or dinitrate You use recreational “poppers” (amyl nitrite) You might need emergency nitrate treatment within ~24 hours after sildenafil use Why this is dangerous Super P-Force contains sildenafil, a PDE5 inhibitor. Nitrates also widen blood vessels. When combined, they can cause: a sudden, severe drop in blood pressure fainting or collapse reduced blood flow to the heart or brain in rare cases, life-threatening cardiovascular events Medical sources consistently classify this as an absolute contraindication (never combine under any circumstances) . Key practical rule If you have taken Super P-Force (or any sildenafil product), you must avoid all nitrate medications for at least 24 hours (often longer depending on dose and health status), unless a doctor in an emergency carefully supervises treatment. Bottom line Super P-Force and nitrates should never be used together at the same time or close together in time — the interaction is considered dangerous and potentially fatal due to severe hypotension.