Duratia 90 mg), activities requiring full alertness until you know how it affects you, and use in people with specific heart, liver, kidney, seizure, or psychiatric conditions. Important details: Alcohol: Do not drink alcohol with Duratia; alcohol increases dizziness, fainting, and other side effects and can make the drug less safe. Medicines to avoid or use with caution: Avoid strong CYP3A4 inhibitors and specific interacting drugs such as monoamine oxidase inhibitors (e.g., selegiline), certain antidepressants and antipsychotics, and drugs that affect serotonin or cause QT prolongation (examples listed by manufacturers). Check with your prescriber before combining medications. Driving and operating machinery: Do not drive or operate heavy machinery until you know how Duratia affects you, because it can cause dizziness and drowsiness. Cardiovascular conditions: Do not use if you have significant heart disease, uncontrolled hypertension or hypotension, or known risk factors for syncope; dapoxetine can cause fainting or postural (orthostatic) hypotension in some patients. Seizure or epilepsy risk: Use is contraindicated or requires caution in people with a history of seizures; stop the drug and seek care if you develop seizures. Liver or kidney impairment: Dose and use may be restricted or contraindicated in moderate–severe hepatic or renal impairment—consult your doctor. Psychiatric conditions and suicidal thoughts: If you develop worsening depression, suicidal ideation, or severe mood changes, stop the medicine and contact a clinician immediately. Blood disorders and bleeding risk: Use caution if you take anticoagulants or drugs affecting platelet function, or if you have a bleeding disorder. Overdose/administration limit: Do not take more than one dose in 24 hours. If you want, I can: Provide a concise list of specific drug classes and examples to avoid with Duratia. Check interactions with any prescription or over‑the‑counter medicines you take (tell me their names).