Tadarise 10 mg (tadalafil) taken as needed for erectile dysfunction, the usual timing is at least 30 minutes before anticipated ***** activity. Many people take it around 30–60 minutes beforehand. It can be taken with or without food. D DailyMed +1 It doesn't cause an automatic erection; ***** stimulation is still required. Its effect can remain useful for up to 36 hours, so you don't need to time ***** as precisely as with sildenafil. D DailyMed Do not take it more than once in 24 hours. Don't use tadalafil with nitrates such as nitroglycerin or with “poppers,” because this can cause a dangerous drop in blood pressure. D DailyMed If you're deciding between Tadarise 10 mg and sildenafil 50 mg, the main difference is the much longer duration of tadalafil.