If Vidalista Black 80 mg is the product you mean, it is marketed as tadalafil 80 mg. That is a very high strength: standard tadalafil labeling for ED uses 5, 10, or 20 mg, with 20 mg as the usual maximum as-needed dose. D DailyMed +1 Medicines to avoid or use only with medical supervision Nitrates — absolutely avoid: nitroglycerin, isosorbide mononitrate/dinitrate, and nitrate “poppers.” Tadalafil + nitrates can cause a dangerous drop in blood pressure. D DailyMed Riociguat — avoid: combining it with tadalafil is contraindicated because of potentially severe hypotension. D DailyMed Other ED medicines — don't combine: sildenafil (Cenforce/Fildena/Malegra), vardenafil (Filitra), or additional tadalafil (Cialis/Vidalista). Combining PDE-5 inhibitors can increase adverse effects and blood-pressure lowering. V Vidalista - Alpha-blockers: tamsulosin, alfuzosin, doxazosin, terazosin, etc. can further lower blood pressure. D DailyMed Some blood-pressure medicines: tadalafil can add to their blood-pressure-lowering effect. D DailyMed Strong CYP3A4 inhibitors: examples include ketoconazole and ritonavir; these can substantially increase tadalafil exposure. D DailyMed Large amounts of alcohol can increase dizziness and low blood pressure. D DailyMed Because 80 mg is far above the standard ED dose, I would not take Vidalista Black 80 mg without a doctor/pharmacist verifying the product and dose. If you give me the names and doses of the medicines you're currently taking, I can check them specifically against tadalafil.