Malegra DXT Plus can sometimes cause muscle pain, but it is not one of the most common side effects. Why muscle pain may happen Malegra DXT Plus contains: Sildenafil Citrate (for erectile dysfunction) Duloxetine (used for mood and nerve-related conditions) Muscle or body pain can occur mainly due to: 1. Sildenafil effect (blood vessel relaxation) Sildenafil Citrate can cause: Muscle aches Back pain Body heaviness This happens because it changes blood flow and relaxes smooth muscles. 2. Duloxetine-related effects Duloxetine may cause: Muscle pain or stiffness (less common) Fatigue or body discomfort Nerve-related sensations in some users 3. Combination effect Since Malegra DXT Plus combines both medicines, some people may feel: General body ache Tiredness with mild muscle soreness Temporary discomfort after taking the tablet When to worry You should contact a doctor if: Muscle pain is severe or persistent You also have chest pain, fainting, or severe dizziness Pain starts after every dose and worsens Simple conclusion Yes, muscle pain is possible but usually mild and uncommon, and it typically happens due to how the body responds to the two active ingredients.