Avana 100 mg contains avanafil, its compatibility with other medicines depends on the specific drug combination. Avanafil can interact with several medicines, so it should not be assumed to be compatible with everything. Nitrates: Avoid completely. Combining avanafil with nitroglycerin or other nitrate medicines can cause a dangerous drop in blood pressure. Alpha-blockers and blood-pressure medicines: May increase the risk of low blood pressure, dizziness, or fainting. Strong or moderate CYP3A4 inhibitors: Medicines such as ketoconazole, ritonavir, clarithromycin, or erythromycin can substantially increase avanafil levels and may require avoidance or dose adjustment. Other ED medicines: Do not combine avanafil with sildenafil, tadalafil, vardenafil, or similar PDE5 inhibitors unless specifically instructed by a healthcare professional. Alcohol: Heavy alcohol consumption can increase the risk of dizziness and low blood pressure. Because 100 mg is a standard as-needed avanafil strength, your other medicines should be reviewed before taking it. If you provide the names of the medicines or supplements you currently use, I can check the potential interactions.