Cenforce Soft contains sildenafil citrate, which is used to treat erectile dysfunction (ED). While sildenafil is primarily broken down by the liver, kidney disease can affect how the drug is cleared from the body, increasing the risk of side effects in some people. Kidney conditions that may impact the safe use of Cenforce Soft include: Severe chronic kidney disease (CKD): Reduced kidney function can slow the elimination of sildenafil metabolites, potentially increasing drug exposure. End-stage kidney disease (ESKD): People receiving dialysis may be more sensitive to the medication and often require careful dose selection and medical supervision. Acute kidney injury (AKI): Temporary loss of kidney function can alter the body's handling of medications, so use should be discussed with a healthcare provider. Kidney disease with significant cardiovascular problems: Since ED medications can lower blood pressure, additional caution is needed in people who also have heart disease. Kidney transplant recipients: Sildenafil may be appropriate for some transplant recipients, but it should only be used after review of kidney function and possible interactions with anti-rejection medications. For people with mild to moderate kidney impairment, dose adjustments are not always necessary, but a healthcare provider may recommend starting with a lower sildenafil dose, particularly in older adults or those with multiple medical conditions.