Tadarise 60 mg (tadalafil) should not be taken twice a day. Tadalafil for erectile dysfunction is generally dosed once per day at most when used as needed, and the usual maximum recommended as-needed dose is 20 mg. Tadalafil can remain effective for up to about 36 hours, so taking another dose the same day can unnecessarily increase drug levels and side effects. F FDA Access Data 60 mg is already a high dose, so taking 60 mg twice daily (120 mg/day) is particularly unsafe unless a specialist has specifically prescribed it for a particular medical reason. Possible effects of excessive tadalafil include severe headache, flushing, dizziness/low blood pressure, rapid heartbeat, vision/hearing problems, and prolonged erection (priapism). If you've already taken 60 mg twice today, tell me how many hours apart the doses were and whether you're having any symptoms, and I can tell you what to do next.