Tadalafil 5 mg once daily is a standard dose for erectile dysfunction for many adults, and the FDA-approved labeling allows starting at 2.5 mg daily and increasing to 5 mg based on effectiveness and tolerability. F FDA Access Data However, whether Tadarise 5 mg is safe for you depends on your health and other medicines. Do not take it with nitrates such as nitroglycerin or isosorbide, or with recreational “poppers.” This combination can cause a dangerous drop in blood pressure. F FDA Access Data Don't combine it with Kamagra, Malegra, sildenafil, or another PDE-5 inhibitor unless a doctor specifically advises it. F FDA Access Data Be cautious with large amounts of alcohol, blood-pressure medicines, and alpha-blockers because blood pressure can fall. F FDA Access Data Seek emergency care for an erection lasting more than 4 hours, or sudden vision/hearing loss. F FDA Access Data Tadalafil can be taken with or without food. F FDA Access Data Since you've mentioned Duratia (dapoxetine) and Kamagra/Malegra (sildenafil), I can also explain the safest way to use Tadarise 5 mg with or without Duratia 30 mg, and which combinations you should avoid.