Cenforce 50 mg (sildenafil) can sometimes be taken with medicines for high blood pressure, but it depends on the specific BP medicine. Sildenafil can lower blood pressure further. Studies have found it can generally be used with several common antihypertensive classes, but caution is needed with some combinations. M Medicines.org.uk +1 ACE inhibitors, ARBs, beta-blockers, diuretics, and many calcium-channel blockers: often can be combined, but your BP and symptoms should be considered. Alpha-blockers such as doxazosin, alfuzosin, or tamsulosin: can cause additional BP lowering and dizziness; medical guidance is recommended. M Medicines.org.uk +1 Nitrates such as nitroglycerin/GTN, isosorbide mononitrate, or isosorbide dinitrate: do not take with sildenafil because the combination can cause a dangerous fall in blood pressure. M Medicines.org.uk If you tell me the exact name and dose of your BP medicine (for example, amlodipine 5 mg, telmisartan 40 mg, etc.), I can check the specific interaction with Cenforce 50 mg.