Malegra 120 contains sildenafil, grapefruit—especially grapefruit juice—can affect it. Grapefruit inhibits CYP3A4, an enzyme that helps break down sildenafil, so it can increase sildenafil exposure. A study found grapefruit juice increased sildenafil exposure by about 23%. P PubMed Because of this, official sildenafil information does not recommend combining sildenafil with grapefruit juice. P Pfizer Labeling With a 120 mg dose, which is higher than the commonly used 50–100 mg ED doses, I'd be particularly cautious about grapefruit and would avoid it around the time you take the medicine. If you've already eaten grapefruit or drunk grapefruit juice, tell me how much and when, and when you plan to take the Malegra 120, and I can explain what that means.